From genengnews.com
Caloric Restriction vs. Intermittent Fasting: Large Mouse Study Offers Insights and Raises Questions
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Findings implied more generally that the effects of dietary restriction on health and lifespan may be partially non-overlapping.
#diet #aging #Health #biology #nutrition #pathology #physiology #Endocrinology
18h ago
From genengnews.com
Squid Game: Direct Drug Delivery Into GI Tract Using Cephalopod-Inspired Capsules
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Researchers have taken inspiration from jet propulsion mechanisms of cephalopods to develop an innovative ingestible capsule.
on Fri, 4PM
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Aggressive Tumor Growth in Drug-Resistant Prostate Cancer Driven by Enzyme
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The enzyme EZH2 has an unexpected role in driving aggressive tumor growth in treatment-resistant prostate cancers.
on Wed, 9PM
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Parkinson’s Symptom, Resting Tremor, Relates to Dopamine in Unexpected Way
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Study suggests that preserved dopamine in certain brain regions may actually contribute to tremor symptoms, challenging common beliefs.
on Tue, 4PM
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Linking Alzheimer’s Risk to Specific Types of Air Pollution
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Research teams are developing air pollution models to measure PM2.5 components in the Atlanta area.
on Tue, 3PM
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Exercise Causes Muscles to Release Myokines, Speeding Neuron Growth
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Findings of cell-based studies suggest that the biochemical and physical effects of exercise could help heal nerves.
on Nov 13
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Researchers Discover New Metabolic Compound That Regulates Body Weight
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It might be possible for people in the future to consume BHB-Phe to drive weight loss without restricting carbohydrates in their diet.
on Nov 13
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New Role for Mutant Proteins in Some Deadly Cancers Discovered
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Novel treatment combinations could one day be developed that take this new role for RAS into consideration.
on Nov 12
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Discovery of Nuclear Roles for Metabolic Enzymes Could Lead to New Anticancer Strategies
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Studies suggest the cell is more interconnected than previously thought, opening up "exciting possibilities for science and medicine."
on Nov 12
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Patient Dies in Beam Trial of SCD Candidate; Company Cites Conditioning
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The patient died four months after BEAM-101 infusion “due to respiratory failure that was determined by the investigator to be likely related to busulfan conditioning and deemed unrelated to BEAM-101,” Beam said in a statement.
on Nov 6
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Evidence of Lung Cancer Detected in Breath Using Ultrasensitive Nanoflake Nanosensors
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Researchers suggest their work represents a breakthrough in low-cost, noninvasive cancer screening through breath analysis.
on Nov 6
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Synthetic Gene Cascades Timed to Control DNA Nanotube Assembly
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Synthetic genes, though few, can generate complex biomolecular materials when their expression is part of a temporal control scheme.
on Nov 5
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High-Speed 3D Bioprinter May Be Game Changer for Drug Discovery
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In addition to improving print speed, dynamic interface printing enables a degree of cell positioning within printed tissues.
on Nov 4
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Ulcerative Colitis Association with Cancer Risk Linked to p53 Tumor Suppressor Gene
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Results provide a mechanistic explanation of why early loss of p53 signaling is frequently observed in UC-associated colorectal carcinogenesis.
on Oct 29
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CRISPR Study Reveals Yet Another Antiviral Mechanism
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CRISPR shown to have a whole new mechanism: Instead of acting like a pair of molecular scissors, it acts like a molecular fumigator.
on Oct 29
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Effects of Mutations on Protein-Protein Interactions Predicted by New AI Tool
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Scientists can use the publicly-available tool to predict how disease-linked mutations impact human protein-protein interactions.
on Oct 25
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Proteomics Could Go Ion-Free with “Fingerprinted” NEMS-MS
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Proteomics that is based on mass spectrometry and keeps proteins intact appears more feasible with NEMS subjected to fingerprint analysis.
on Oct 23
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Exploring the Gut-Brain Connection: Uncovering Its Mysteries
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The disruption of abnormal activity in the gut microbiome may increase our risk for neurological disease, research suggests.
on Oct 18
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Selfish DNA May Prevent Developmental Regression in Human Embryos
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Results suggest novel roles for LINE1 transposable elements that can be explored in the contexts of diseases, from neurological disorders to cancer.
on Oct 18
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Wave Clinical Trial Shows First Successful RNA Editing in Humans
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Wave Life Sciences' alpha-1 antitrypsin deficiency candidate WVE-006 succeeded in the first-ever clinical demonstration of RNA editing in humans by achieving positive proof-of-mechanism in an early-phase clinical trial.
on Oct 17
From genengnews.com
Baker, Hassabis, Jumper Awarded Nobel Prize in Chemistry for Protein Design and Structure Prediction
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David Baker won the 2024 prize for computational protein design while Demis Hassabis and John M. Jumper won for protein structure prediction.
on Oct 9
From genengnews.com
Microbiome Demographics More Granular with Single-Cell Genomics
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Microbiomes may be subjected to single-cell genomics to show how individual bacteria swap genetic material, including antibiotic resistance genes.
on Oct 8
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Old Chemo Drug Is New Again Because It Can Attack Different Cancers Differently
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Researchers hope to plan clinical trials of 5-fluorouracil with drugs that would enhance its RNA-damaging effects and kill cancer cells more effectively.
on Oct 8
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In a First, Complete Connectome of Every Neuron in the Drosophila Brain Mapped
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The first wiring diagram of every neuron in an adult brain, and the 50 million connections between them, has been produced for Drosophila.
on Oct 3
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Genes Activating Old Neural Stem Cells May Counteract Decline During Aging
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Study sheds hopeful new light on how and why neural stem cells become less active as brains age.
on Oct 3
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Ovarian Cancer: Early Detection with AI-Aided Biomarker Analysis
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AI-powered analysis of multianalyte liquid biopsies could be an accessible way to improve ovarian cancer screening.
on Oct 1
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Rheumatoid Arthritis Study IDs Macrophages That Could Hasten Diagnosis, Treatment
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Study identifies pro-inflammatory macrophage subtype with distinct genetic features in inflamed joints of RA patients.
on Oct 1
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Crohn’s Disease Organoids Show Two Molecular Subtypes for Personalized Therapeutics
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Researchers say work is underway to genotype the two CD subtypes in order to develop a simple test that can identify which subtype a patient falls into.
on Sep 30
From genengnews.com
IVF Could Be Improved If Disused “Pause Button” in Embryos Is Pressed
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IVF could be improved if a "lost" mechanism to control the pace of human embryonic development could be restored.
on Sep 30
From genengnews.com
New Drug Targets Both Drug-Sensitive and Drug-Resistant Malaria
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MED6-189 targets and disrupts the parasite’s apicoplast and also vesicular trafficking pathways, a dual mode of action that prevents the pathogen from developing resistance.
on Sep 27
From genengnews.com
DeepRVAT AI Model Predicts Effects of Rare Genetic Variants
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Researchers suggest the DeepRVAT model is the first to use artificial intelligence (AI) in genomic association studies to decipher rare genetic variants.
on Sep 26
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Nvidia Launches AI Reference Workflow for Drug Discoverers
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NIM Agent Blueprint based on cloud-native "microservices" aim to accelerate virtual screening of small molecules using generative models.
on Sep 26
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The Antimicrobial Resistance Crisis Eradicating a Global Health Threat
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TAXIS Pharmaceuticals highlights strategies for targeting the core mechanisms of resistance and shares a vision of a more resilient world.
on Sep 25
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Prostate Cancer’s Spread Modeled with CRISPR Barcoding Technology
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Preclinical mouse model using CRISPR reveals the complicated routes prostate cancer metastatic cells take as they travel through the body.
on Sep 24
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PTSD from Brain Injury Could Be Treated with Targeted Magnetic Stimulation
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Researchers analyzed datasets to study brain circuitry that might be causally linked to PTSD in military veterans.
on Sep 24
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Origami-Paper Sensors Detect Infectious Pathogens in Wastewater in Real-time
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The sensors detect roughly 20 copies of pathogenic RNA per reaction sample and offers comparable specificity and sensitivity to PCR testing.
on Sep 21
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Drug Screen Suggests Antidepressant Could Be Repurposed to Fight Glioblastoma
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Research in cell cultures and mice demonstrates an antidepressant called vortioxetine may be effective in combating glioblastomas.
on Sep 20
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Antibodies Targeting S. aureus Sugar Identified as Key to Fighting Infection
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Researchers say findings “directly challenge the current way of thinking about staphylococcal infections.”
on Sep 18
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How the Brain Rebuilds: New Insights into Myelin Regeneration
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C1QL1 promotes the replacement of the cells that produce myelin. Boosting it may improve treatment of demyelinating diseases.
on Sep 14
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Damaged DNA in Colorectal Cancer Chemo Patients Might Be Repaired More Effectively with New Therapy
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A new process, nucleophagy, repairs damaged DNA that is particularly relevant for patients undergoing colorectal cancer treatment.
on Sep 13
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Leveraging Proteomics for Precision Cancer Research, Diagnosis, and Treatment
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Daniel Hornburg, PhD, Torsten Mueller, PhD, and Stefan Foser, PhD, of Bruker Daltonics describe how proteomics can help researchers survey the molecular landscape of cancer. Don't miss this September issue thought leader article.
on Sep 10
From genengnews.com
Accelerate Screening and Characterization of Proteins
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Quantum-Si describes how protein barcodes and Next-Generation Protein Sequencing™ can expedite diverse applications and reduce costs and labor requirements.
on Sep 10
From genengnews.com
ChatGPT-Like Platform for Digital Pathology Shows Promise in Cancer Diagnostics
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The researchers' ambition was to create a nimble, versatile ChatGPT-like AI platform that can perform a broad range of cancer evaluation tasks.
on Sep 7
From genengnews.com
Genetic Analysis of Bacterial Strains Causing Lyme Disease Could Transform Treatment
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A team developed web-based software tools (BorreliaBase.org) to enable scientists to compare Borrelia genomes.
on Aug 16
From genengnews.com
Antibiotics Could Target Bacterial Protein Found to Maintain Envelope Integrity
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Further studying OpgH enzymes and their function could help scientists identify new antibacterial drug targets
on Aug 16
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Pancreatic Cancer Could Be Detected Sooner with Nanoprobe-Based Blood Test
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Researchers suggest strategy could lead to significantly more precise and reliable pancreatic cancer diagnosis.
on Aug 13
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Alzheimer’s Plaques Co-Accumulate with Potential Biomarker or Target Proteins
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Alzheimer’s could be driven by amyloid plaque indirectly, via signaling proteins that co-accumulate with amyloid.
on Aug 13
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Protein Counting Technique Improves Analysis of Microscopy Images
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A new method for measuring the degree of protein labeling improves the quantitative analysis of microscopy images.
on Aug 10
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BCG Vaccine: A Breakthrough in Bladder Cancer Treatment
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Scientists demonstrate how the BCG vaccine leads to the destruction of bladder cancer cells.
on Aug 10
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Breast Cancer’s Spread to Brain Could Be Treated by Antibody-Drug Conjugate
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Researchers say newly reported data support ongoing investigation of Sacituzumab Govitecan ADC in a Phase 2 clinical trial against recurrent glioblastoma.
on Aug 9