From nih.gov
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Our findings therefore support the potential of periodic theta parameters as biomarkers of depression-severity; and periodic low gamma parameters and cognitive measures as biomarkers of mPFC DBS treatment efficacy. They also support sample entropy and the aperiodic spectral parameters as potential c …
#brains #Ketamine #biomarkers #depression #psychedelic #mentalhealth #neuroscience #psychedelics #antidepressant #deepbrainstimulation
18h ago
From nih.gov
[Applications of high performance liquid chromatography-mass spectrometry in proteomics] - PubMed
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Proteomics profiling plays an important role in biomedical studies. Proteomics studies are much more complicated than genome research, mainly because of the complexity and diversity of proteomic samples. High performance liquid chromatography-mass spectrometry (HPLC-MS) is a fundamental tool in prot …
18h ago
From nih.gov
[Progress in enrichment methods for protein N-phosphorylation] - PubMed
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Protein phosphorylation is one of the most common and important post-translational modifications that regulates almost all life processes. In particular, protein phosphorylation regulates the development of major diseases such as tumors, neurodegenerative diseases, and diabetes. For example, excessi …
19h ago
From nih.gov
[Microbial metaproteomics--From sample processing to data acquisition and analysis] - PubMed
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Microorganisms are closely associated with human diseases and health. Understanding the composition and function of microbial communities requires extensive research. Metaproteomics has recently become an important method for throughout and in-depth study of microorganisms. However, major challenges …
20h ago
From nih.gov
[Applications of chromatography in glycomics] - PubMed
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Glycomics, an emerging "omics" technology that was developed after genomics and proteomics, is a discipline that studies the composition, structure, and functions of glycomes in cells, tissues, and organisms. Glycomics plays key roles in understanding the laws of major life activities, disease preve …
22h ago
From nih.gov
1 1
Lysine (K) is widely used in the design of lysine-targeted crosslinkers, structural elucidation of protein complexes, and analysis of protein-protein interactions. In "shotgun" proteomics, which is based on liquid chromatography-tandem mass spectrometry (LC-MS/MS), proteins from complex samples are …
on Sat, 9AM
From nih.gov
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Strength training exercise regimens demonstrated the highest efficacy in reducing migraine burden, followed by high-intensity aerobic exercise.
on Fri, 7PM
From nih.gov
Pressure and perverse flights to familiarity - PubMed
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Under pressure, people often prefer what is familiar, which can seem safer than the unfamiliar. We show that such favoring of familiarity can lead to choices precisely contrary to the source of felt pressure, thus exacerbating, rather than mitigating, its negative consequences. In Experiment 1, time …
on Fri, 2PM
From nih.gov
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Current Controlled Trials ISRCTN05681227 ClinicalTrials.gov NCT02325544.
on Fri, 12PM
From nih.gov
Artificial intelligence and illusions of understanding in scientific research - PubMed
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Scientists are enthusiastically imagining ways in which artificial intelligence (AI) tools might improve research. Why are AI tools so attractive and what are the risks of implementing them across the research pipeline? Here we develop a taxonomy of scientists' visions for AI, observing that their a …
on Fri, 9AM
From nih.gov
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It is often suggested that coffee causes dehydration and its consumption should be avoided or significantly reduced to maintain fluid balance. The aim of this study was to directly compare the effects of coffee consumption against water ingestion across a range of validated hydration assessment tech …
on Thu, 10PM
From nih.gov
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The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-COV-2), which is causing the coronavirus disease-2019 (COVID-19) pandemic, poses a global health threat. However, it is easy to confuse COVID-19 with seasonal influenza in preliminary clinical diagnosis. In this study, the differ …
on Thu, 8PM
From nih.gov
Infant Deaths After Texas' 2021 Ban on Abortion in Early Pregnancy - PubMed
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This study found that Texas' 2021 ban on abortion in early pregnancy was associated with unexpected increases in infant and neonatal deaths in Texas between 2021 and 2022. Congenital anomalies, which are the leading cause of infant death, also increased in Texas but not the rest of the US. Although …
on Thu, 7PM
From nih.gov
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This study examined the association between prenatal cannabis exposure and autism spectrum disorder (ASD) diagnoses and traits. A total sample of 11,570 children (ages 1-18; 53% male; 25% Hispanic; 60% White) from 34 cohorts of the National Institutes of Health-funded environmental influences on chi …
on Thu, 12PM
From nih.gov
0 4
Creatine supplementation improves sit-to-stand performance, muscle function, and lean tissue mass. It is crucial to conduct high-quality prospective RCTs to confirm these hypotheses (PROSPERO number, CRD42023354929).
on Wed, 12AM
From nih.gov
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The explosion in Mendelian randomization (MR) publications is hard to ignore and shows no signs of slowing. Clinician readers, who may not be familiar with jargon-ridden methods, are expected to discern the good from the many low-quality studies that make overconfident claims of causality or stretch …
on Tue, 4PM
From nih.gov
Subjective brain fog: a four-dimensional characterization in 25,796 participants - PubMed
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This is the largest study characterising subjective brain fog as an impairment of concentration associated with functional impairments in activities of daily living. Brain fog was particularly associated with a history of long-COVID-19, migraines, concussion, and with 0.1 standard deviations lower c …
on Mon, 11PM
From nih.gov
NIH-sponsored trial of nasal COVID-19 vaccine opens
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Candidate vaccine could provide enhanced breadth of protection against emerging SARS-CoV-2 variants.
on Mon, 8PM
From nih.gov
Coffee reduces the risk of death after acute myocardial infarction: a meta-analysis - PubMed
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Drinking coffee habitually following AMI was associated with a reduced risk of mortality.
on Mon, 7AM
From nih.gov
Most Americans don’t know that primary care physicians can prescribe addiction treatment
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NIH-supported study reveals crucial need to increase public awareness that medications for opioid use disorder can be prescribed in primary care settings.
on Mon, 2AM
From nih.gov
Cognitive impairment among older American Indians
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The prevalence of cognitive impairment among older American Indians may be higher than previously thought, according to a new analysis.
on Sun, 7PM
From nih.gov
NCBI @ ISMB & BOSC 2024 - NCBI Insights
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We look forward to seeing you at the Intelligent Systems for Molecular Biology Conference (ISMB) and Bioinformatics Open Science Conference (BOSC) meetings taking place July 12-16, 2024 in-person in Montréal, Canada and virtually.
on Sun, 4PM
From nih.gov
Iota-carrageenan neutralizes SARS-CoV-2 and inhibits viral replication in vitro - PubMed
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In the absence of a vaccine and other effective prophylactic or therapeutic countermeasures the severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) remains a significant public health threat. Attachment and entry of coronaviruses including SARS-CoV-2 is mainly mediated by the spike …
on Jun 29
From nih.gov
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This study aimed to determine the effects of different concentrations of 1-methyl cyclopropene (1-MCP) on the nutritional quality, antioxidant enzyme activities, and volatile compounds of "Hangjiao No.2" chili pepper during 12 days of storage at ambient temperature. The chili fruit were randomly sel …
on Jun 29
From nih.gov
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An 86-year-old male patient with sustained virological response of chronic hepatitis type C was diagnosed with hepatocellular carcinoma (HCC) in hepatic segment 3. He was treated with transcatheter arterial chemoembolization (TACE) and radiation therapy because the tumor was located at the edge of t …
on Jun 28
From nih.gov
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Defensive endosymbiotic bacteria conferring protection to their hosts against parasites and pathogens are widespread in insect populations. However, the mechanisms by which most symbionts confer protection are not fully understood. Here, we studied the mechanisms of protection against bacterial and …
on Jun 28
From nih.gov
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This study examined the associations between violence victimization, homelessness, and severe mental illness (SMI) among people who use opioids (PWUOs) in three U.S. cities. We analyzed data from a cross-sectional survey conducted from May 2019 to February 2020 across three study sites: Los Angeles, …
on Jun 28
From nih.gov
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Knowledge about the chemical composition of floral volatile organic compounds (VOCs) is valuable in biological studies as well as for the flavor, cosmetic, and fragrance industries. The flowers of Chinese chestnut (Castanea mollissima) emit a distinctive semen-like odor; however, the chemical compos …
on Jun 27
From nih.gov
A virtual rodent predicts the structure of neural activity across behaviors - PubMed
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Animals have exquisite control of their bodies, allowing them to perform a diverse range of behaviors. How such control is implemented by the brain, however, remains unclear. Advancing our understanding requires models that can relate principles of control to the structure of neural activity in beha …
on Jun 27
From nih.gov
A Modern ClinicalTrials.gov Website - NCBI Insights
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Classic website no longer available effective June 25, 2024 We appreciate all the feedback received since the launch of the modernized ClinicalTrials.gov website in June 2023, and we’ve incorporated many of your suggestions. As announced last month, the classic website has remained available to...
on Jun 27
From nih.gov
The Importance of Reporting Your At-Home COVID-19 Test Results
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MakeMyTestCount.org lets people report the test results they get at home.
on Jun 26
From nih.gov
For healthy adults, taking multivitamins daily is not associated with a lower risk of death
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Findings come from an NIH analysis of more than two decades of dietary data from 390,124 U.S. adults.
on Jun 26
From nih.gov
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Should environmental, social, and economic sustainability be of primary concern to engineers? Should social justice be among these concerns? Although the deterioration of our natural environment and the increase in social injustices are among today's most pressing and important issues, engineering c …
on Jun 26
From nih.gov
Lithium in the public water supply and suicide mortality in Texas - PubMed
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There is increasing evidence from ecological studies that lithium levels in drinking water are inversely associated with suicide mortality. Previous studies of this association were criticized for using inadequate statistical methods and neglecting socioeconomic confounders. This study evaluated the …
on Jun 26
From nih.gov
0 0
High pathogenicity avian influenza viruses (HPAIVs) of the H5N1 and H5N2 subtypes were responsible for 84 HPAI outbreaks on poultry premises in Japan during October 2022-April 2023. The number of outbreaks during the winter of 2022-2023 is the largest ever reported in Japan. In this study, we perfor …
on Jun 26
From nih.gov
0 0
Acetylcysteine | C5H9NO3S | CID 12035 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
on Jun 26
From nih.gov
0 0
Although the emergence of the Omicron variants of SARS-CoV-2 has diminished the protective effects of vaccination against infection with SARS-CoV-2, updating our earlier model to incorporate loss of immunity, diminished vaccine efficacy and a longer time horizon, does not qualitatively change our ea …
on Jun 26
From nih.gov
0 0
Outbreaks of influenza A viruses are generally seasonal and cause annual epidemics worldwide. Due to their frequent reassortment and evolution, annual surveillance is of paramount importance to guide vaccine strategies. The aim of this study was to explore the molecular epidemiology of influenza A v …
on Jun 26
From nih.gov
Less Than 2 °C Warming by 2100 Unlikely - PubMed
0 1
The recently published Intergovernmental Panel on Climate Change (IPCC) projections to 2100 give likely ranges of global temperature increase in four scenarios for population, economic growth and carbon use<sup>1</sup>. However these projections are not based on a fully statistical approach. Here we …
on Jun 26
From nih.gov
0 0
Neuroimaging studies have identified the anterior cingulate cortex (ACC) as one of the major targets of ketamine in the human brain, which may be related to ketamine's antidepressant (AD) mechanisms of action. However, due to different methodological approaches, different investigated populations, a …
on Jun 26
From nih.gov
0 0
Prevalence of Past-Year Alcohol Use Disorder (AUD) People Ages 12 and Older
on Jun 26
From nih.gov
A transcription factor atlas of directed differentiation - PubMed
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Transcription factors (TFs) regulate gene programs, thereby controlling diverse cellular processes and cell states. To comprehensively understand TFs and the programs they control, we created a barcoded library of all annotated human TF splice isoforms (>3,500) and applied it to build a TF Atlas …
on Jun 26
From nih.gov
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We documented a substantial relative risk of pulmonary embolism and a large absolute risk difference of abdomen-related symptoms after SARS-CoV-2 infection during the Delta variant period. As new SARS-CoV-2 variants emerge, researchers and clinicians should monitor patients for changing symptoms and …
on Jun 26
From nih.gov
How excess niacin may promote cardiovascular disease
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Findings about a metabolite of niacin, or vitamin B3, raise concerns about the health effects of too much niacin and suggest new measures to help prevent or treat cardiovascular disease
on Jun 26
From nih.gov
Adrenal cell affects parental behavior in mice
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Researchers traced differences in parental care between two mouse species to a new cell type in the adrenal glands.
on Jun 26
From nih.gov
Urine test identifies high-risk prostate cancers
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Researchers developed a urine-based test that can distinguish between slow-growing prostate cancers that pose little risk and more aggressive cancers that need treatment.
on Jun 26
From nih.gov
Plastic particles in bottled water
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Researchers developed an imaging technique that detected thousands of tiny bits of plastic in common single-use bottles of water.
on Jun 26
From nih.gov
The Future of Scientific Conferencing
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This virtual workshop will bring together diverse perspectives from multiple disciplines to explore advantages, barriers, gaps, and opportunities in the future of scientific conferencing for the behavioral and social sciences. Areas of particular focus will include technological innovations that...
on Jun 26