From nih.gov
2 2
Perceptions of Tourette syndrome (TS) and tic disorders are often driven by social media. During the COVID-19 pandemic, social media consumption greatly increased, particularly in the adolescent population. In parallel with increased social media consumption, ...
on Sep 6
From nih.gov
2 2
Youth with longer durations and more frequent episodes of homelessness have substantially poorer health outcomes. The association of longer duration to poorer health persisted in multivariate models. Longer duration of unsheltered homelessness may drive the onset of physical and mental health proble …
on Jan 30
From nih.gov
Dementia in the Ancient Greco-Roman World Was Minimally Mentioned - PubMed
1 1
The modern 'epidemic level' of advanced dementias was not described among ancient Greco-Roman elderly. The possible emergence of advanced ADRD in the Roman era may be associated with environmental factors of air pollution and increased exposure to lead. Further historical analysis may formulate crit …
4h ago
From nih.gov
1 1
This review highlights a substantial gap between the recognition of cybersecurity risks in MDs and the guidance on their incorporation into the BRA. Standardized frameworks are needed to provide clear methods for evaluating cybersecurity risks and their impact on the safety and security of MDs.
#infosec #hackerman #healthcare #cybersecurity #medicaldevices
13h ago
From nih.gov
Stepfamily Variation in Parent-Child Relationship Quality in Later Life - PubMed
1 1
This study underscores the importance of considering mothers' and fathers' different points of view in the same family and examining both positive and negative parent-child interactions as negative relationships are not merely the reverse of positive relationships.
on Oct 4
From nih.gov
1 1
Our work suggests that objective greenspace exposure is only one factor influencing peoples' perceived greenspace exposure, and that environmental attitude variables may play an additional role in shaping peoples' perceptions.
on Sep 9
From nih.gov
1 1
We provide a comprehensive quantification of both VE and VE waning. These findings can guide policymakers to help evaluate the COVID-19 vaccination programme and minimise the effect of future COVID-19 in Aotearoa New Zealand.
on Sep 6
From nih.gov
Humanizing Pedophilia as Stigma Reduction: A Large-Scale Intervention Study
1 1
The stigmatization of people with pedophilic sexual interests is a topic of growing academic and professional consideration, owing to its potential role in moderating pedophiles’ emotional well-being, and motivation and engagement in child abuse ...
#gay #human #lgbtq #minors #lesbian #StopHate #research #logically #pedophile #questions
on Sep 5
From nih.gov
The Therapeutic Role of Ketogenic Diet in Neurological Disorders
1 1
The ketogenic diet (KD) is a high-fat, low-carbohydrate and adequate-protein diet that has gained popularity in recent years in the context of neurological diseases (NDs). The complexity of the pathogenesis of these diseases means that effective forms ...
on Sep 5
From nih.gov
1 1
Undoubtedly, mask mandates during the SARS-CoV-2 pandemic have been generating an additional source of potentially harmful exposition to toxins with health threatening and carcinogenic properties at population level with almost zero distance to the airways.
on Sep 5
From nih.gov
NIH-sponsored trial of nasal COVID-19 vaccine opens
1 1
Candidate vaccine could provide enhanced breadth of protection against emerging SARS-CoV-2 variants.
on Jul 1
From nih.gov
0 1
Ketamine displays efficacious rapid-acting antidepressant (RAAD) activity in the rat chronic mild stress (CMS) model. It rapidly reverses anhedonia (CMS-induced sucrose consumption deficit) and attenuates working memory deficit (novel object recognition: NOR) following both systemic (intraperitoneal …
on Wed, 4PM
From nih.gov
Netrin-1: Key insights in neural development and disorders - PubMed
0 1
Netrin-1, an essential extracellular protein, has gained significant attention due to its pivotal role in guiding axon and cell migration during embryonic development. The fundamental significance of netrin-1 in developmental biology is reflected in its high conservation across different species as …
on Wed, 12PM
From nih.gov
0 1
The functional specialization of CD4 T lymphocytes into various subtypes, including T<sub>H</sub>1 and T<sub>FH</sub> cells, is crucial for effective immune responses. T<sub>FH</sub> cells facilitate B cell differentiation within germinal centers, while T<sub>H</sub>1 cells are vital for cell-mediat …
on Wed, 12PM
From nih.gov
0 1
Taking inspiration from diverse interlocking and adhesion structures found in nature, a biaxially interlocking interface is developed in this work. This interface is formed by interconnecting two electrostatically flocked substrates and its mechanical strength is enhanced through the incorporation o …
on Wed, 12PM
From nih.gov
0 1
Cholangiocarcinoma (CCA) is an aggressive cancer of the bile duct epithelium. Anthocyanins are water-soluble flavonoids that contribute to the color of fruits and pigmented rice. Black rice bran is rich in anthocyanin pigments and exhibits certain health benefits, including anticancer activity; howe …
on Wed, 11AM
From nih.gov
0 1
Among those visiting a testing centre in Toronto, ON, between March and April 2020, people experiencing homelessness (n = 214) were more likely to test positive for COVID-19 compared with those not experiencing homelessness (n = 1,836) even after ...
on Wed, 5AM
From nih.gov
0 1
These findings reveal a novel mechanism linking TRPV4 to valve stiffening, providing insights into how extracellular matrix mechanical properties drive inflammation and fibrosis in AVS.
on Wed, 5AM
From nih.gov
0 1
Three umami substances (glutamate, 5'-inosinate, and 5'-guanylate) were found by Japanese scientists, but umami has not been recognized in Europe and America for a long time. In the late 1900s, umami was internationally recognized as the fifth basic taste based on psychophysical, electrophysiologica …
on Wed, 1AM
From nih.gov
0 1
In the circulatory system, the microenvironment surrounding cancer cells is complex and involves multiple coupled factors. We selected two core physical factors, shear stress and hydraulic resistance, and constructed a microfluidic device with dual negative inputs to study the trade-off movement beh …
on Wed, 12AM
From nih.gov
Intense Sweetness Surpasses Cocaine Reward - PMC
0 1
Refined sugars (e.g., sucrose, fructose) were absent in the diet of most people until very recently in human history. Today overconsumption of diets rich in sugars contributes together with other factors to drive the current obesity epidemic. ...
on Tue, 7PM
From nih.gov
0 1
Osteoarthritis (OA) is a prevalen degenerative joint disease with no FDA-approved therapies that can halt or reverse its progression. Current treatments address symptoms like pain and inflammation, but not underlying disease mechanisms. OA progression is marked by increased inflammation and extracel …
on Tue, 6PM
From nih.gov
0 1
The engraftment of haematopoietic stem and progenitor cells (HSPCs), particularly in cord-blood transplants, remains challenging. Here we report the role of the corticotropin-releasing hormone (CRH) in enhancing the homing and engraftment of human-cord-blood HSPCs in bone marrow through mechanical r …
on Tue, 6AM
From nih.gov
0 1
Black Americans experience the death of a parent much earlier in the life course than White Americans on average. However, studies have not considered whether the cardiovascular health consequences of early parental death vary by race. Using data from the National Longitudinal Study of Adolescent to …
on Tue, 1AM
From nih.gov
Analgesic Use and the Risk of Hearing Loss in Men - PMC
0 2
Hearing loss is a common sensory disorder, yet prospective data on potentially modifiable risk factors are limited. Regularly used analgesics, the most commonly used drugs in the US, may be ototoxic and contribute to hearing loss. We examined the ...
on Mon, 7PM
From nih.gov
0 1
The study reveals that the heterodimeric kinesin-2 motor KIF3AC and its adaptor RCP are crucial for polarized formation of focal adhesions at the front of migrating fibroblasts. KIF3AC and RCP associate with intracellularly recycling integrin to promote its return to the cell surface after its endoc …
on Mon, 6PM
From nih.gov
Programming the elongation of mammalian cell aggregates with synthetic gene circuits - PubMed
0 1
A key goal of synthetic morphogenesis is the identification and implementation of methods to control morphogenesis. One line of research is the use of synthetic genetic circuits guiding the self-organization of cell ensembles. This approach has led to several recent successes, including control of c …
on Mon, 6PM
From nih.gov
A generalized theoretical framework to investigate multicomponent actin dynamics - PubMed
0 1
The length of actin filaments is regulated by the combined action of hundreds of actin-binding proteins. While the roles of individual proteins are well understood, how they combine to regulate actin dynamics in vivo remains unclear. Recent advances in microscopy have enabled precise, high-throughpu …
on Mon, 6PM
From nih.gov
0 2
Emerging adults in the U.S. face significant economic uncertainty during the early life course. Economic uncertainties grew in the 2000s, especially for the Millennial cohort. Access to credit can be a resource to manage the instability that characterizes emerging adulthood. However, debt can also b …
on Mon, 6PM
From nih.gov
0 1
The extracellular matrix (ECM) is a complex meshwork comprising over 100 proteins. It serves as an adhesive substrate for cells and, hence, plays critical roles in health and disease. We have recently identified a novel ECM protein, SNED1, and have found that it is required for neural crest cell mig …
on Mon, 6PM
From nih.gov
0 1
The extracellular matrix (ECM) is a non-cellular three-dimensional structure present in all tissues that is essential for the intestinal maintenance, function and structure, as well as for providing physical support for tissue integrity and elasticity. ECM enables the regulation of various processes …
on Mon, 5PM
From nih.gov
Dynamics of β-cardiac myosin between the super-relaxed and disordered-relaxed states - PubMed
0 1
The super-relaxed (SRX) state of myosin ATPase activity is critical for striated muscle function, and its dysregulation is linked to cardiomyopathies. It is unclear whether the SRX state exchanges readily with the disordered-relaxed (DRX) state, and whether the SRX state directly corresponds to the …
on Mon, 5PM
From nih.gov
0 1
This study investigates the effect of adopting right-to-work on unfair labor practice charges filed at the National Labor Relations Board. Most charges accompany union elections, which are expected to decrease under right-to-work. However, this work's synthetic control method results show that unfai …
on Mon, 4PM
From nih.gov
0 1
Intra‐host diversity is an intricate phenomenon related to immune evasion, antiviral resistance, and evolutionary leaps along transmission chains. SARS‐CoV‐2 intra‐host variation has been well‐evidenced from respiratory samples. However, data on ...
on Mon, 3PM
From nih.gov
0 2
Both IMD and CRD can improve the various anthropometric, clinical, imaging and biochemical parameters but IMD was superior to CRD in terms of reducing CAP values and weight/BMI over 180 days in overweight/obese NAFLD children.
on Mon, 1PM
From nih.gov
Discovery of MDI-114215: A Potent and Selective LIMK Inhibitor To Treat Fragile X Syndrome - PubMed
0 1
LIMKs are serine/threonine and tyrosine kinases responsible for controlling cytoskeletal dynamics as key regulators of actin stability, ensuring synaptic health through normal synaptic bouton structure and function. However, LIMK1 overactivation results in abnormal dendritic synaptic development tha …
on Mon, 12PM
From nih.gov
0 1
What morphologies are more likely to appear during evolution is a central question in zoology. Here we offer a novel approach to this question based on first developmental principles. We assumed that morphogenesis results from the genetic regulation of cell properties and behaviors (adhesion, contra …
on Mon, 12PM
From nih.gov
The myth of vaccination and autism spectrum - PMC
0 1
Among all of the studied potential causes of autism, vaccines have received some of the most scrutiny and have been the topic of many evidence-based studies. These efforts have led the great majority of scientists, physicians, and public health ...
on Mon, 12PM
From nih.gov
Beyond D-luciferin: Expanding the Scope of Bioluminescence Imaging in vivo - PMC
0 1
The light-emitting chemical reaction catalyzed by the enzyme firefly luciferase is widely used for noninvasive imaging in live mice. However, photon emission from the luciferase is critically dependent on the chemical properties of its substrate, ...
on Mon, 10AM
From nih.gov
Kurtosis as Peakedness, 1905 – 2014. R.I.P - PMC
0 1
The incorrect notion that kurtosis somehow measures “peakedness” (flatness, pointiness or modality) of a distribution is remarkably persistent, despite attempts by statisticians to set the record straight. This article puts the notion to rest once ...
on Mon, 8AM
From nih.gov
0 1
The role of immune cells is crucial in nerve regeneration following spinal cord injury. Kif15, a member of the kinesin family, has been shown to enhance macrophage phagocytosis. This study investigates the impact of Kif15 deficiency on immune cells in zebrafish with spinal cord injury. Using kif15 m …
on Mon, 5AM
From nih.gov
The Dual Roles of Lamin A/C in Macrophage Mechanotransduction - PubMed
0 1
Cellular mechanotransduction is a complex physiological process that integrates alterations in the external environment with cellular behaviours. In recent years, the role of the nucleus in mechanotransduction has gathered increased attention. Our research investigated the involvement of lamin A/C, …
on Mon, 5AM
From nih.gov
C5a impairs phagosomal maturation in the neutrophil through phosphoproteomic remodeling - PMC
0 1
Critical illness is accompanied by the release of large amounts of the anaphylotoxin, C5a. C5a suppresses antimicrobial functions of neutrophils which is associated with adverse outcomes. The signaling pathways that mediate C5a-induced neutrophil ...
on Sun, 8PM
From nih.gov
Mesenchymal Cell Contractility Regulates Villus Morphogenesis and Intestinal Architecture - PubMed
0 1
The large absorptive surface area of the small intestine is imparted by finger-like projections called villi. Villi formation is instructed by stromal-derived clusters of cells which have been proposed to induce epithelial bending through actomyosin contraction. Their functions in the elongation of …
on Sun, 6AM
From nih.gov
0 1
During tissue morphogenesis, an interplay of biochemical pathways and mechanical cues regulates polarized cell behaviors, the balance of which leads to tissues reaching their correct shape and size.<sup>1</sup><sup>,</sup><sup>2</sup><sup>,</sup><sup>3</sup><sup>,</sup><sup>4</sup> A well-studied ex …
on Sun, 5AM
From nih.gov
[What Actin and Myosin Do in the Nucleus: New Functions of the Well-Known Proteins] - PubMed
0 1
The functions of actin and its motor proteins myosins in the cytoplasm have been the subject of research for more than 100 years, but the existence and function of these proteins in the nucleus has been a matter of debate until recently. Recent data has clarified the role of actin and myosin molecul …
on Sun, 5AM
From nih.gov
Cancer Treatment as an Accelerated Aging Process: Assessment, Biomarkers, and Interventions - PubMed
0 1
An accumulating body of evidence supports the hypothesis that cancer and/or cancer treatment is associated with accelerated aging. The majority of these data come from the pediatric literature; however, a smaller yet growing body of literature points toward similar findings in the geriatric populati …
on Sun, 5AM
From nih.gov
0 1
Preclinical evidence indicates the potential anti-tumor capabilities of cannabinoids in prostate cancer (PC). We undertook a cross-sectional study using National Survey on Drug Use and Health data from 2002 to 2020, involving 2503 participants in the USA. The independent variable was marijuana use s …
on Sun, 4AM
From nih.gov
Conformational response of αIIbβ3 and αVβ3 integrins to force - PubMed
0 1
As major adhesion receptors, integrins transmit biochemical and mechanical signals across the plasma membrane. These functions are regulated by transitions between bent and extended conformations and modulated by force. To understand how force on integrins mediates cellular mechanosensing, we compar …
on Sat, 11PM
From nih.gov
0 1
Septin 9 (SEPT9), a GTPase, known as the fourth cytoskeleton, is widely expressed in various cells and tissues. The functions of SEPT9 are partly similar to other cytoskeletons as a structure protein. Further, SEPT9 can interact with other cytoskeletons, participating in actin dynamics and microtubu …
on Sat, 11PM