biorxiv.org
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Global comparative structural analysis of responses to protein phosphorylation
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Post-translational modifications (PTMs), particularly protein phosphorylation, are key regulators of cellular processes, impacting numerous aspects of protein activity. Despite widespread phosphorylation of eukaryotic proteomes, the function of most phosphosites remains unknown. Elucidating the...
#protein #bioinformatics #structuralbiology
16h ago
From biorxiv.org
Transposable elements are prevalent vectors of transgenerational epigenetic inheritance in nature
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Transgenerational epigenetic inheritance (TEI) mediated by transposable elements (TEs) is well established in plants. However, the molecular determinants and functional impact of this additional system of inheritance are poorly characterized. Through comprehensive analyses of severe DNA...
22h ago
From biorxiv.org
Decipher Fundamental Atomic Interactions to Unify Generative Molecular Docking and Design
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Atomic interactions are fundamental to molecular structures and functions. We constructed PocketXMol, an all-atom AI model, to learn these interactions for general pocket-interacting molecular generative tasks. PocketXMol unified distinct molecular tasks under a single computational framework...
5h ago
From biorxiv.org
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Surfactants and film-forming polymers are common ingredients in consumer spray products such as cleaning products, hair care products, and anti-perspirants. Spraying eases application by creating aerosolised droplets of the product that can distribute evenly over the treated surface. However,...
5h ago
From biorxiv.org
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The opportunistic pathogen Pseudomonas aeruginosa counts on a large collection of two-component regulatory systems (TCSs) to sense and adapt to changing environments. Among them, the Roc (Regulation of cup) system is a one-of-a-kind network of branched TCSs, composed of two histidine kinases...
22h ago
From biorxiv.org
miR-210 locus deletion disrupts cellular homeostasis; an integrated genetic study
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MiR-210 is widely recognized as the quintessential hypoxia-responsive miRNA and thought to fine-tune various facets of cellular homeostasis. We hereby present an integrative appraisal of phenotypic and molecular repercussions of disrupting the corresponding locus in human and mouse cells using...
16h ago
From biorxiv.org
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ISG15's dual role in cancer biology still remains unclear. One major area requiring further investigation is the molecular mechanisms underlying ISG15's pro- and anti-tumorigenic roles in different cancer types. In this study, we try to find the probable pathways that could be influenced by...
20h ago
From biorxiv.org
Cooperative motility emerges in crowds of T cells but not neutrophils
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T cells are among the most motile immune cells in the body, and their migration into and within tissues is key to their function. Remarkably, T cells can maintain their motility even in highly crowded environments like the densely packed T cell areas of lymphoid organs, but how they do so...
5h ago
