#cell
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From arxiv.org
A self-organised liquid reaction container for cellular memory
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Epigenetic inheritance during cell division is essential for preserving cell identity by stabilizing the overall chromatin organisation.Heterochromatin,the condensed and transcriptionally silent fraction of chromatin,is marked by specific epigenetic modifications that are diluted during each...
17h ago
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From arxiv.org
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A low pressure discharge sustained in molecular hydrogen with help of the electron cyclotron resonance heating at a frequency of 2.45 GHz is simulated using a fully electromagnetic implicit charge- and energy-conserving particle-in-cell/Monte Carlo code. The simulations show a number of kinetic...
17h ago
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From arxiv.org
The geometric nature of homeostatic stress in biological growth
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Morphogenesis, the process of growth and shape formation in biological tissues, is driven by complex interactions between mechanical, biochemical, and genetic factors. Traditional models of biological growth often rely on the concept of homeostatic Eshelby stress, which defines an ideal target...
17h ago
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From arxiv.org
Spiral waves speed up cell cycle oscillations in the frog cytoplasm
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Spiral waves are a well-known phenomenon in excitable media, playing critical roles in biological systems such as cardiac tissues, where they are involved in arrhythmias, and in slime molds, where they guide collective cell migration. However, their presence in the cytoplasm of cells has not...
#q #cell #nlin #physics #cellmigration
17h ago
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From nih.gov
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The role of immune cells is crucial in nerve regeneration following spinal cord injury. Kif15, a member of the kinesin family, has been shown to enhance macrophage phagocytosis. This study investigates the impact of Kif15 deficiency on immune cells in zebrafish with spinal cord injury. Using kif15 m …
17h ago
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From nih.gov
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What morphologies are more likely to appear during evolution is a central question in zoology. Here we offer a novel approach to this question based on first developmental principles. We assumed that morphogenesis results from the genetic regulation of cell properties and behaviors (adhesion, contra …
10h ago
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From nih.gov
Programming the elongation of mammalian cell aggregates with synthetic gene circuits - PubMed
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A key goal of synthetic morphogenesis is the identification and implementation of methods to control morphogenesis. One line of research is the use of synthetic genetic circuits guiding the self-organization of cell ensembles. This approach has led to several recent successes, including control of c …
4h ago
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From biorxiv.org
Programming the elongation of mammalian cell aggregates with synthetic gene circuits
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A key goal of synthetic morphogenesis is the identification and implementation of methods to control morphogenesis. One line of research is the use of synthetic genetic circuits guiding the self-organization of cell ensembles. This approach has led to several recent successes, including control...
4h ago
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From biorxiv.org
Transcriptional control of C. elegans male tail tip morphogenesis by DMD-3
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Sexual dimorphic morphogenesis is governed by DM-domain transcription factors (TFs) in many animals, but how these transcriptional control links to the morphogenetic mechanisms is insufficiently known. The DM-domain TF DMD-3 in C. elegans is the master regulator of a male-specific development...
7h ago
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From biorxiv.org
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Human endocrine cell differentiation and islet morphogenesis play critical roles in determining islet cell mass and function, but the events and timeline of these processes are incompletely defined. To better understand early human islet cell development and maturation, we collected 115...
on Sun, 10PM
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From biorxiv.org
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Three copper(II) complexes containing 1,10-phenanthroline ([CuCl2(phen)].4H2O), neocuproine ([CuCl2(neo)].4H2O) and tetramethyl-phenanthroline ([CuCl2(tmp)].4H2O) as the primary ligand and another three copper(II) complexes with the L-Ala-Phe dipeptide as an auxiliary ligand:...
17h ago
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From biorxiv.org
Cryogenic light microscopy with Ångstrom precision deciphers structural conformations of PIEZO1
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Despite the impressive progress in molecular biochemistry and biophysics, many questions regarding the conformational states of large (transmembrane) protein complexes persist. In the case of the PIEZO protein, investigations by cryogenic electron microscopy (Cryo-EM) and atomic force microscopy...
17h ago
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From biorxiv.org
Spatially ordered zygotic genome activation fulfills embryo quality control
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Early embryo development features autonomous, maternally-driven cell divisions that self-organize the multicellular blastula or blastocyst tissue. Maternal control cedes to the zygote starting with the onset of widespread zygotic genome activation (ZGA), which is essential for subsequent cell...
10h ago
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From biorxiv.org
Endocytic Patch Dynamics are Differentially Regulated at Distinct Cell Sites in Fission Yeast
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Endocytosis promotes polarity and growth in eukaryotes. In Schizosaccharomyces pombe fission yeast, endocytosis occurs at the polarized cell ends and division site and at the non-polarized cell sides. Our characterization of endocytic actin patches show that they are differentially regulated....
5h ago
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From biorxiv.org
Spatiotemporal Regulatory Logics of Mouse Gastrulation
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Spatiotemporal coordination of cellular and molecular events is crucial for cell fate commitment during mouse gastrulation. However, the high-precision mechanisms governing the timing and spatial dynamics remain poorly understood. Here, we present a time-series single-cell multi-omic dataset...
6h ago
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From biorxiv.org
Size-dependent temporal decoupling of morphogenesis and transcriptional programs in gastruloids
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Understanding the interplay between cell fate specification and morphogenetic changes remains a central challenge in developmental biology. Gastruloids, self-organizing stem cell-based models of post-implantation mammalian development, provide a powerful platform to address this question. Here,...
8h ago
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From biorxiv.org
Dynamic p21-dependency during quiescence arrest unveiled by a rapid p21 depletion system
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p21 inhibits CDK2 activity to induce quiescence in response to stress or developmental stimulation. It is currently unclear whether p21 exhibits an equal functional importance across different stages and states of the quiescence arrest. Here employing a rapid p21 degradation system, we evaluate...
7h ago
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