• Trends
  • Topics
  • Nodes
Search for keywords, #hashtags, $sites, add a dash to exclude, e.g. -$theonion.com

From biorxiv.org

Gene expression is globally regulated by interacting nucleobase supply and mRNA composition demand: a mechanism disrupted by multiple disease states and drug treatments

1 1

Conventional expression studies quantify messenger RNA (mRNA) transcript levels gene-by-gene. We recently showed that protein expression is modulated at a global scale by amino acid availability, suggesting that mRNA expression levels might be similarly affected by nucleobase supply. Re-analysis...

#cell #celldivision

3h ago

From nih.gov

Programming the elongation of mammalian cell aggregates with synthetic gene circuits - PubMed

1 1

A key goal of synthetic morphogenesis is the identification and implementation of methods to control morphogenesis. One line of research is the use of synthetic genetic circuits guiding the self-organization of cell ensembles. This approach has led to several recent successes, including control of c …

#cell #morphogenesis

10h ago

From biorxiv.org

Programming the elongation of mammalian cell aggregates with synthetic gene circuits

1 1

A key goal of synthetic morphogenesis is the identification and implementation of methods to control morphogenesis. One line of research is the use of synthetic genetic circuits guiding the self-organization of cell ensembles. This approach has led to several recent successes, including control...

#cell #morphogenesis

10h ago

From biorxiv.org

Endocytic Patch Dynamics are Differentially Regulated at Distinct Cell Sites in Fission Yeast

1 1

Endocytosis promotes polarity and growth in eukaryotes. In Schizosaccharomyces pombe fission yeast, endocytosis occurs at the polarized cell ends and division site and at the non-polarized cell sides. Our characterization of endocytic actin patches show that they are differentially regulated....

#cell #Dynamics

11h ago

From biorxiv.org

Spatiotemporal Regulatory Logics of Mouse Gastrulation

1 1

Spatiotemporal coordination of cellular and molecular events is crucial for cell fate commitment during mouse gastrulation. However, the high-precision mechanisms governing the timing and spatial dynamics remain poorly understood. Here, we present a time-series single-cell multi-omic dataset...

#cell #Dynamics

12h ago

From biorxiv.org

Transcriptional control of C. elegans male tail tip morphogenesis by DMD-3

1 1

Sexual dimorphic morphogenesis is governed by DM-domain transcription factors (TFs) in many animals, but how these transcriptional control links to the morphogenetic mechanisms is insufficiently known. The DM-domain TF DMD-3 in C. elegans is the master regulator of a male-specific development...

#cell #morphogenesis

13h ago

From biorxiv.org

Dynamic p21-dependency during quiescence arrest unveiled by a rapid p21 depletion system

1 1

p21 inhibits CDK2 activity to induce quiescence in response to stress or developmental stimulation. It is currently unclear whether p21 exhibits an equal functional importance across different stages and states of the quiescence arrest. Here employing a rapid p21 degradation system, we evaluate...

#cell #Dynamics

13h ago

From biorxiv.org

Size-dependent temporal decoupling of morphogenesis and transcriptional programs in gastruloids

1 1

Understanding the interplay between cell fate specification and morphogenetic changes remains a central challenge in developmental biology. Gastruloids, self-organizing stem cell-based models of post-implantation mammalian development, provide a powerful platform to address this question. Here,...

#cell #morphogenesis

14h ago

From biorxiv.org

Spatially ordered zygotic genome activation fulfills embryo quality control

1 1

Early embryo development features autonomous, maternally-driven cell divisions that self-organize the multicellular blastula or blastocyst tissue. Maternal control cedes to the zygote starting with the onset of widespread zygotic genome activation (ZGA), which is essential for subsequent cell...

#cell #morphogenesis

16h ago

From nih.gov

A Morphospace Exploration Using a General Model of Development Reveals a Basic Set of Morphologies for Early Animal Development and Evolution - PubMed

1 1

What morphologies are more likely to appear during evolution is a central question in zoology. Here we offer a novel approach to this question based on first developmental principles. We assumed that morphogenesis results from the genetic regulation of cell properties and behaviors (adhesion, contra …

#cell #morphogenesis

16h ago

From arxiv.org

A self-organised liquid reaction container for cellular memory

1 1

Epigenetic inheritance during cell division is essential for preserving cell identity by stabilizing the overall chromatin organisation.Heterochromatin,the condensed and transcriptionally silent fraction of chromatin,is marked by specific epigenetic modifications that are diluted during each...

#cell #physics #celldivision

22h ago

From arxiv.org

Spiral waves speed up cell cycle oscillations in the frog cytoplasm

1 1

Spiral waves are a well-known phenomenon in excitable media, playing critical roles in biological systems such as cardiac tissues, where they are involved in arrhythmias, and in slime molds, where they guide collective cell migration. However, their presence in the cytoplasm of cells has not...

#q #cell #nlin #physics #cellmigration

22h ago

From nih.gov

Kif15 regulates Coro1a+ cell migration and phagocytosis in zebrafish after spinal cord injury - PubMed

1 1

The role of immune cells is crucial in nerve regeneration following spinal cord injury. Kif15, a member of the kinesin family, has been shown to enhance macrophage phagocytosis. This study investigates the impact of Kif15 deficiency on immune cells in zebrafish with spinal cord injury. Using kif15 m …

#cell #kinesin #cellmigration

22h ago

From arxiv.org

The geometric nature of homeostatic stress in biological growth

1 1

Morphogenesis, the process of growth and shape formation in biological tissues, is driven by complex interactions between mechanical, biochemical, and genetic factors. Traditional models of biological growth often rely on the concept of homeostatic Eshelby stress, which defines an ideal target...

#cell #physics #morphogenesis

23h ago

From arxiv.org

Electromagnetic particle-in-cell modeling of an electron cyclotron resonance plasma discharge in hydrogen

1 1

A low pressure discharge sustained in molecular hydrogen with help of the electron cyclotron resonance heating at a frequency of 2.45 GHz is simulated using a fully electromagnetic implicit charge- and energy-conserving particle-in-cell/Monte Carlo code. The simulations show a number of kinetic...

#cell #physics #pressure

23h ago

From biorxiv.org

Role of the NHE1 exchanger in the antitumor effects of copper(II) complexes and phenanthroline derivatives

1 1

Three copper(II) complexes containing 1,10-phenanthroline ([CuCl2(phen)].4H2O), neocuproine ([CuCl2(neo)].4H2O) and tetramethyl-phenanthroline ([CuCl2(tmp)].4H2O) as the primary ligand and another three copper(II) complexes with the L-Ala-Phe dipeptide as an auxiliary ligand:...

#cell #cellmigration

23h ago

From biorxiv.org

Cryogenic light microscopy with Ångstrom precision deciphers structural conformations of PIEZO1

1 1

Despite the impressive progress in molecular biochemistry and biophysics, many questions regarding the conformational states of large (transmembrane) protein complexes persist. In the case of the PIEZO protein, investigations by cryogenic electron microscopy (Cryo-EM) and atomic force microscopy...

#cell #force

23h ago