From biorxiv.org

Tumour-derived gliogenesis sustains dedifferentiation-dependent tumour growth in the Drosophila CNS

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Fate-restricted cells can acquire stem cell-like properties through dedifferentiation, enabling them to gain the plasticity required for differentiation into multiple lineages. Tumour plasticity is prominently observed in brain cancers, where transient cell state changes are linked to resistance...

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14h ago

From biorxiv.org

Gene expression is globally regulated by interacting nucleobase supply and mRNA composition demand: a mechanism disrupted by multiple disease states and drug treatments

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Conventional expression studies quantify messenger RNA (mRNA) transcript levels gene-by-gene. We recently showed that protein expression is modulated at a global scale by amino acid availability, suggesting that mRNA expression levels might be similarly affected by nucleobase supply. Re-analysis...

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19h ago

From arxiv.org

A self-organised liquid reaction container for cellular memory

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Epigenetic inheritance during cell division is essential for preserving cell identity by stabilizing the overall chromatin organisation.Heterochromatin,the condensed and transcriptionally silent fraction of chromatin,is marked by specific epigenetic modifications that are diluted during each...

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